Gukenera imiti
COVID-19 iterwa no kwandura igitabo cyitwa SARS-CoV-2 pathogen, cyinjira kandi cyinjira mu ngirabuzimafatizo binyuze muri poroteyine yacyo.Kugeza ubu, ku isi hose hari dosiye zirenga miliyoni 138.3, aho abapfuye bagera kuri miliyoni eshatu.
Nubwo inkingo zemewe gukoreshwa byihutirwa, haribazwa ingaruka zazo kuri zimwe mu mpinduka nshya.Byongeye kandi, gukingira byibuze 70% byabaturage mubihugu byose byisi birashoboka ko bizatwara igihe kirekire, urebye umuvuduko winkingo uriho, ikibazo cyo kubura inkingo, nibibazo bya logistique.
Isi iracyakenera imiti ikora neza kandi itekanye, kugirango rero yivange muburwayi bukomeye buterwa niyi virusi.Isubiramo ryubu ryibanda kubikorwa bya buri muntu hamwe no guhuza ibikorwa bya curcumin na nanostructures kurwanya virusi.

Gukenera imiti
COVID-19 iterwa no kwandura igitabo cyitwa SARS-CoV-2 pathogen, cyinjira kandi cyinjira mu ngirabuzimafatizo binyuze muri poroteyine yacyo.Kugeza ubu, ku isi hose hari dosiye zirenga miliyoni 138.3, aho abapfuye bagera kuri miliyoni eshatu.
Nubwo inkingo zemewe gukoreshwa byihutirwa, haribazwa ingaruka zazo kuri zimwe mu mpinduka nshya.Byongeye kandi, gukingira byibuze 70% byabaturage mubihugu byose byisi birashoboka ko bizatwara igihe kirekire, urebye umuvuduko winkingo uriho, ikibazo cyo kubura inkingo, nibibazo bya logistique.
Isi iracyakenera imiti ikora neza kandi itekanye, kugirango rero yivange muburwayi bukomeye buterwa niyi virusi.Isubiramo ryubu ryibanda kubikorwa bya buri muntu hamwe no guhuza ibikorwa bya curcumin na nanostructures kurwanya virusi.

Kurcumin
Curcumin ni uruganda rwa polifenolike rutandukanijwe na rhizome yikimera cya turmeric, Curcuma longa.Igizwe na curcuminoide nini muri iki gihingwa, kuri 77% yumubare wose, mugihe curcumin ntoya igizwe na 17%, naho curcumin III igizwe na 3%.
Curcumin yaranzwe kandi yizwe neza, nka molekile karemano ifite imiti.Kwihanganirana n'umutekano byanditse neza, hamwe na dose ntarengwa ya 12 g / kumunsi.
Imikoreshereze yacyo yasobanuwe nka anti-inflammatory, anticancer, na antioxidant, ndetse na virusi.Curcumin yatanzwe nka molekile ifite ubushobozi bwo gukiza ibihaha hamwe nizindi nzira mbi zitera fibrosis nyuma ya COVID-19.

Curcumin ibuza imisemburo ya virusi
Ibi bikekwa ko biterwa nubushobozi bwayo bwo guhagarika virusi ubwayo, ndetse no guhindura inzira zitera.Igenga kwanduza virusi no kugenzura, ihuza imbaraga nyinshi na enzyme nyamukuru ya protease (Mpro) urufunguzo rwo kwigana kandi ikabuza kwanduza virusi no kwinjira muri selile.Irashobora kandi guhagarika imiterere ya virusi.
Umubare wacyo urwanya virusi zirimo virusi ya hepatite C, virusi ya immunodeficiency ya muntu (VIH), virusi ya Epstein-Barr na virusi ya grippe A.Byavuzwe ko bibuza protease nka 3C (3CLpro) neza kurusha ibindi bicuruzwa bisanzwe, harimo quercetin, cyangwa ibiyobyabwenge nka chloroquine na hydroxychloroquine.
Ibi birashobora kugabanya umuvuduko wa virusi mungirangingo yumuntu byihuse kuruta iyindi miti itabuza, bityo bikarinda indwara kwandura syndrome de acide respiratory (ARDS).
Irabuza kandi protease isa na papain (PLpro) hamwe na 50% yibuza (IC50) ya 5.7 µM irenze quercetin nibindi bicuruzwa bisanzwe.

Curcumin ibuza kwakira reseptor
Virusi ifata abantu bakira selile ya reseptor, angiotensin-ihindura enzyme 2 (ACE2).Ubushakashatsi bwikitegererezo bwerekanye ko curcumin ibuza iyi mikoranire ya virusi na reseptor muburyo bubiri, mukubuza proteine ​​spike na reseptor ya ACE2.
Nyamara, curcumin ifite bioavailable nkeya, kuko idashonga neza mumazi kandi ntigihinduka mubitangazamakuru byamazi, cyane cyane kuri pH yo hejuru.Iyo itanzwe mu kanwa, ihura na metabolisme yihuse n'amara n'umwijima.Izi nzitizi zirashobora kuneshwa ukoresheje nanosystems.
Benshi mubatwara nanostructures barashobora gukoreshwa kubwiyi ntego, nka nanoemuliyoni, microemuliyoni, nanogels, micelles, nanoparticles na liposomes.Abatwara ibintu nk'ibi birinda metabolike gusenyuka kwa curcumin, byongera imbaraga zayo kandi bikayifasha kunyura mubinyabuzima.
Ibicuruzwa bitatu cyangwa byinshi bishingiye kuri curcumin ibicuruzwa bimaze kuboneka mubucuruzi, ariko ubushakashatsi buke bwasuzumye imikorere yabyo kuri COVID-19 muri vivo.Ibi byerekanaga ubushobozi bwimikorere yo guhindura ibisubizo byumubiri no kugabanya ibimenyetso byindwara, kandi byihuta gukira.